The Set Up: Steven Weber and Mel Brooks go to a vampire's grave to kill her undead spirit. Weber drives a stake through her heart and thereby gets his hands -- and his face and hair and chest -- soaked in a geyser's worth of vampire blood.
The Gag: "She just ate!" says Van Helsing, after the first explosion of blood hits Weber in the face.

Dracula: Dead and Loving It, Steven Weber, 1995. © Columbia. Photo Courtesy of the Everett Collection.