While other actors have portrayed him on-screen, Anthony Hopkins's Hannibal "The Cannibal" Lecter is the definitive version -- and the definitive villain. Beyond being a merciless, psycho craving for human flesh, this former psychiatrist terrifies by virtue of his ability to get into your head.

Who is the greatest villain? Click here to vote.

The Silence of the Lambs, Anthony Hopkins, 1991. © Orion Pictures. Photo courtesy of the Everett Collection.